Santosh K Sandur Selected Research

plumbagin

11/2019	Modulation of Caspase-3 activity using a redox active vitamin K3 analogue, plumbagin, as a novel strategy for radioprotection.
2/2015	Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2).
4/2014	Plumbagin, a vitamin K3 analogue, abrogates lipopolysaccharide-induced oxidative stress, inflammation and endotoxic shock via NF-κB suppression.
8/2010	Plumbagin inhibits proliferative and inflammatory responses of T cells independent of ROS generation but by modulating intracellular thiols.
1/2010	5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
6/2006	Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.

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Santosh K Sandur Research Topics

Disease

28	Neoplasms (Cancer) 01/2022 - 06/2006
4	Graft vs Host Disease (Graft-Versus-Host Disease) 05/2016 - 08/2010
3	Carcinogenesis 01/2021 - 06/2006
3	Lymphoma (Lymphomas) 02/2015 - 01/2013
2	Radiation Injuries (Radiation Sickness) 05/2021 - 03/2014
2	Lung Neoplasms (Lung Cancer) 12/2020 - 01/2016
2	Body Weight (Weight, Body) 01/2020 - 11/2019
2	T-Cell Lymphoma (Lymphoma, T Cell) 10/2017 - 02/2015
2	Inflammation (Inflammations) 12/2016 - 04/2014
2	Prostatic Neoplasms (Prostate Cancer) 05/2016 - 01/2014
2	Neoplasm Metastasis (Metastasis) 01/2007 - 01/2006
1	COVID-19 05/2022
1	Dermatitis 01/2021
1	Infections 12/2020
1	Hypoxia (Hypoxemia) 12/2020
1	Acute Radiation Syndrome 01/2020
1	Blister (Bulla) 11/2019
1	Necrosis 03/2016
1	Type 2 Diabetes Mellitus (MODY) 01/2015
1	Shock 04/2014
1	Endotoxemia 04/2014
1	Hepatitis 10/2012
1	Multiple Myeloma 01/2010
1	Colorectal Neoplasms (Colorectal Cancer) 10/2009
1	Rectal Neoplasms (Rectal Cancer) 10/2009

Drug/Important Bio-Agent (IBA)

8	NF-kappa B (NF-kB)IBA 01/2013 - 01/2006
6	plumbaginIBA 11/2019 - 06/2006
6	Transcription Factors (Transcription Factor)IBA 12/2016 - 06/2006
4	CurcuminIBA 05/2022 - 01/2006
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2006
4	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2015 - 08/2010
3	mitocurcuminIBA 05/2022 - 11/2019
3	Vitamin K 3 (Menadione)FDA Link 02/2015 - 08/2011
2	Thioredoxin-Disulfide ReductaseIBA 01/2022 - 01/2016
2	Protein SIBA 01/2021 - 02/2015
2	ThioredoxinsIBA 10/2017 - 01/2016
2	baicaleinIBA 10/2017 - 05/2016
2	AntioxidantsIBA 01/2013 - 01/2012
2	CytokinesIBA 01/2012 - 08/2010
2	Phosphotransferases (Kinase)IBA 01/2010 - 12/2006
2	Cyclin D1IBA 12/2006 - 01/2006
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2006 - 01/2006
2	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 11/2006 - 01/2006
1	Radiation-Protective Agents (Radiation Protectants)IBA 05/2021
1	Biological ProductsIBA 05/2021
1	Conditioned Culture MediaIBA 01/2021
1	AutoantigensIBA 12/2020
1	Oxygen (Dioxygen)IBA 12/2020
1	1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)IBA 01/2019
1	ascorbyl monostearate (ascorbyl stearate)IBA 12/2016
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 12/2016
1	FlavonoidsIBA 05/2016
1	DNA (Deoxyribonucleic Acid)IBA 05/2016
1	troxerutinIBA 05/2016
1	perhydroxyl radicalIBA 03/2016
1	Radiation-Sensitizing AgentsIBA 01/2016
1	dimethoxycurcuminIBA 01/2016
1	LactonesIBA 12/2015
1	withaferin AIBA 12/2015
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 02/2015
1	CaspasesIBA 02/2015
1	Mitogen-Activated Protein Kinase PhosphatasesIBA 02/2015
1	pramlintide (Symlin)FDA Link 01/2015
1	Islet Amyloid PolypeptideIBA 01/2015
1	Protein Isoforms (Isoforms)IBA 01/2015
1	LipopolysaccharidesIBA 04/2014
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2013
1	schizandrin BIBA 10/2012
1	dibenzocyclooctadieneIBA 10/2012
1	TriterpenesIBA 01/2012
1	Interleukin-6 (Interleukin 6)IBA 01/2012
1	Ursolic AcidIBA 01/2012
1	Carboxylic AcidsIBA 01/2012
1	InterleukinsIBA 01/2010
1	buteinIBA 06/2007
1	ZyflamendIBA 01/2007
1	SurvivinIBA 12/2006
1	Transforming Growth Factor alpha (TGF-alpha)IBA 12/2006
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 12/2006
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 12/2006
1	SolutionsIBA 12/2006
1	Epidermal Growth Factor (EGF)IBA 12/2006
1	CarcinogensIBA 11/2006
1	Viral ProteinsIBA 11/2006
1	SmokeIBA 11/2006
1	indirubinIBA 08/2006
1	Methylcellulose (BFL)IBA 01/2006
1	TNF Receptor-Associated Factor 1IBA 01/2006
1	Inhibitor of Apoptosis ProteinsIBA 01/2006
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2006
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2006
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2006
1	EnzymesIBA 01/2006
1	Fas-Associated Death Domain Protein (Fas-Associating Protein with Death Domain)IBA 01/2006

Therapy/Procedure

7	Radiotherapy 01/2022 - 10/2009
5	Therapeutics 01/2022 - 12/2006
2	Transplantation 01/2020 - 01/2012
1	Oral Administration 01/2020
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 10/2012
1	Traditional Medicine (Folk Remedies) 01/2006